Hycult Biotech/Factor H，小鼠，单克隆抗体1A2，FITC/HM1119F/100µg
商品编号：
HM1119F
品牌：
hycultbiotech
市场价：
¥7752.00
美元价：
4651.20
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:FactorH,Mouse,mAb1A2,FITC
Monoclonalantibody1A2recognizesmousecomplementfactorH(CFH).CFHisthefirstregulatoryproteinofthealternativepathwayofthecomplementsystem.Therearethreepathwaysofcomplementactivation;classical,alternative,andlectinactivationpathway.ThesepathwaysconvergetoformC3/C5convertasesthatgenerateC3a,C3b,C5a,andC5b,eachwithsubstantialBIOLOGicactivity.Complementregulatorsarenecessarytopreventtheinjudiciousproductionofthesemediatorsandpotentialinjurytoself-tissue.TheplasmaproteinsCFH,C4-bindingproteinandthecellmembraneproteinscomplementreceptor1(CR1;CD35),decay-acceleratingfactor(CD55),andmembraneco-factorprotein(CD46)allaremembersoftheregulatorsofcomplementactivationfamily.TheseproteinshavenaturalaffinityforC3band/orC4b,whichconfersonthemtheABIlitytoacceleratetheintrinsicdecayofC3/C5convertasesand/oractasco-factorforthecleavageandinactivation(i)ofC3bandC4bbycomplementfactorI(CFI).
GenetichumananalysesrevealsaclearassociationofCFHwithdifferenthumandiseases.Theseincludediseasesofthekidney,theatypicalformofHemolyticUremicSyndrome(aHUS)andmembranoproliferativeglomerulonephritis(MPGN).FurThermore,CFHisassociatedwithage-relatedmaculardegeneration(AMD),adiseaseoftheeye.
GenetichumananalysesrevealsaclearassociationofCFHwithdifferenthumandiseases.Theseincludediseasesofthekidney,theatypicalformofHemolyticUremicSyndrome(aHUS)andmembranoproliferativeglomerulonephritis(MPGN).FurThermore,CFHisassociatedwithage-relatedmaculardegeneration(AMD),adiseaseoftheeye.
Specifications:
| Catalognumber | HM1119F |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100μg/ml)0.2μmfilteredproteinGpurifiedFITCconjugatedantibodysolutioninPBS,containing1%bovineserumalbuminand0.02%sodiumazide. |
| Conjugate | FITC |
| Application | Frozensections,Immunoassays,Westernblot |
| ApplicationNotes | IA:Antibody1A2canbeusedasacaptureanddetectionantibody. |
| Use | Dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Immunogen | MousefactorH-humanIgGfusionprotein |
| Isotype | MouseIgG1 |
| Species | Mouse |
| Crossreactivity | Rat-Yes |
| Alias | CFH,ComplementFactorH,Proteinbeta-1-H Genename:Cfh,Hf1 |
| References | 1.Vu,Detal;EnhancedBacteremiainHumanFactorHTransgenicRatsInfectedbyNeisseriameningitides.InfecandImmun2012,80:643 |
| Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforatleastoneyear |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Autoimmunity,Nephrology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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