Hycult Biotech/S100A9，小鼠，单克隆抗体MU14-2A5/HM1102/100µg
商品编号：
HM1102
品牌：
hycultbiotech
市场价：
¥7752.00
美元价：
4651.20
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description: S100A9, Mouse, mAb MU14-2A5
The monoclonal antibody MU14-2A5 recognizes S100A9. The calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. MRP14 is co-expressed with human MRP8, a homologue protein in myeloid cells, and plays an essential role in calcium dependent functions during inflammation. This role includes the activation of Mac-1, the β2 integrin which is involved in neutrophil adhesion to endothelial cells. MRP14 is distinguished from other S100 member proteins by its long C-terminal region.
The expression of MRP-8 (S100A8) and MRP-14 (S100A9) is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process. The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. In inflammatory conditions small venueles stain with both anti-S100A8 and S100A9. The staining of the two subunits is always coincident. The S100A8/A9 complex has antibacterial, antifungal and immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils.
The expression of MRP-8 (S100A8) and MRP-14 (S100A9) is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process. The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. In inflammatory conditions small venueles stain with both anti-S100A8 and S100A9. The staining of the two subunits is always coincident. The S100A8/A9 complex has antibacterial, antifungal and immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils.
Specifications:
| Catalog number | HM1102 |
|---|---|
| Product type | Monoclonal antibodies |
| Quantity | 100 µg |
| Formulation | 1 ml (100 μg/ml) 0.2 μm protein G purified antibody solution in PBS, containing 0.1% bovine serum albumin. |
| Application | Frozen sections, Functional studies, Immuno assays, Immuno fluorescence, Paraffin sections, Western blot |
| Application Notes | W: A reduced sample treatment and SDS-Page was used. The band size is 13-15 kDa. |
| Use | Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. |
| Immunogen | Complete mouse S100A9 protein |
| Isotype | Rat IgG1 |
| Species | Mouse |
| Cross reactivity | Rabbit - No |
| Alias | Migration inhibitory factor-related protein 14, MRP 14, Calgranulin B Gene name: S100a9, Cagb, Mrp14 |
| Positive Control | Mouse bone marrow cell extracts |
| Storage and stability | Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label. |
| Precautions | For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result from the use or derivation of this product. |
| Disease | Gastroenterology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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