4000-520-616
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当前位置: 首页 > 产品中心 > monoclonal_antibody > Hycult Biotech/TNF-RI,小鼠,单克隆抗体55R-170/HM1097/100µg
商品详细Hycult Biotech/TNF-RI,小鼠,单克隆抗体55R-170/HM1097/100µg
Hycult Biotech/TNF-RI,小鼠,单克隆抗体55R-170/HM1097/100µg
Hycult Biotech/TNF-RI,小鼠,单克隆抗体55R-170/HM1097/100µg
商品编号: HM1097
品牌: hycultbiotech
市场价: ¥6432.00
美元价: 3859.20
产地: 美国(厂家直采)
公司:
产品分类: 单克隆抗体
公司分类: monoclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Description:TNF-RI,Mouse,mAb55R-170

Themonoclonalantibody55R-170recognizestheextracellularpartofmouseTumorNecrosisFactorReceptorsuperfamilymember1A(TNF-RI),alsoknownasCD120aorp55.TNF-RIbelongstothelargeTNFreceptorfamily,amongwhichTNF-RII(TNF-Rp75-80),lymphotoxin-betareceptor(LTbetaR)andtheHerpesvirusentrymediator(HVEM).LigandsforthesereceptorsbelongtotheTumorNecrosisFactor(TNF)superfamilyofcytokines,whichactivatesignalingpathwaysforcellsurvival,death,anddifferentiationthatorchestratethedevelopment,organizationandhomeostasisoflymphoid,mammary,neuronalandectodermaltissues.TNF-RIcontainsacharacteristicstructuralcassettetermeddeathdomaininitssequencethatisconservedwithinadistinctsubsetofotherTNF-Rfamilymembers,suchasCD95,DR3,DR4,andDR5.Thisdeathdomain,wascharacterizedasbeingessentialforinductionofapoptosisinvitroandhasbeenstructurallyconservedwithintheseTNF-Rsuperfamilymembers.DeletionofthedeathdomainoftheTNF-RIresultsinanon-functionalreceptor,indicatingthatthedeathdomainisrequiredforthesignaltransductionofthephysiologicalfunctionsofTNF-RIinvivo.TNF-RIisa55kDtypeItransmembraneproteinandisexpressedonavarietyofcelltypesatlowlevels.ItisconsideredtoplayaprominentroleincellstimulationbyTNF-alpha.InductionofcytotoxicityandotherfunctionsaremediatedlargelyviaTNF-RI.TNF-RIispresentassolubleforminbodyfluids(forinstanceplasmaandCSF).ThisextracellularTNF-RIisgeneratedbytwomechanisms,namelyproteolyticcleavageofTNF-RIectodomainsandreleaseoffull-lengthTNF-RIinthemembranesofexosome-likevesicles.TNF-RIandTNF-RIIbothinteractwiththehomomericformsofLTbetaorTNF.However,TNF-RIfunctionsasthehighaffinityreceptorforsolubleTNF(sTNF).TNF-RIhasbeenshowntobeinvolvedinawidevarietyofinflammatorydiseases,amongwhichneurodegenerativediseases(Parkinson"sandAlzheimer"sdisease),multiplesclerosis,asthma,atherosclerosis,rheumatology.Themonoclonalantibody55R-170alsorecognizesthesolublereceptor..

Specifications:

CatalognumberHM1097
ProducttypeMonoclonalantibodies
Quantity100µg
Formulation1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin.
ApplicationFlowcytometry,Functionalstudies,Immunoassays,Immunoprecipitation
UseForflowcytometry,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser"sexperimentalsetting.
ImmunogenPurifiedsolubleextracellulardomainofmouseTNF-RI
IsotypeArmenianhamsterIgG
SpeciesMouse
AliasTNFRtypeI,CD120a,TNF-RI,TNF-R55,TNFRp55,p55-R,TNFreceptoralphachain
References1.Sheehan,Ketal;Monoclonalantibodiesspecificformurinep55andp75tumornecrosisfactorreceptors:identificationofanovelinvivoroleforp75.JExpMed1995,181:607
2.Pinckard,Jetal;Ligand-inducedformationofp55andp75tumornecrosisfactorreceptorheterocomplexesonintactcells.JBiolChem1997,272:10784
3.Ji,Hetal;Criticalrolesforinterleuking1andtumornecrosisfactoralphainantibody-inducedarthritis.JExpMed2002,196:77
4.Lee,Setal;InhibitionofTCR-inducedCD8TcelldeathbyIL-12:regulationofFasligandandcellularFLIPexpressionandcaspaseactivationbyIL-12.JImmunol2003,170:2456
StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.
PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct.
DiseaseAutoimmunity,Gastroenterology
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。