4000-520-616
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当前位置: 首页 > 产品中心 > monoclonal_antibody > Hycult Biotech/MHC I类,小鼠,单克隆抗体ER-MP42/HM1091/100µg
商品详细Hycult Biotech/MHC I类,小鼠,单克隆抗体ER-MP42/HM1091/100µg
Hycult Biotech/MHC I类,小鼠,单克隆抗体ER-MP42/HM1091/100µg
Hycult Biotech/MHC I类,小鼠,单克隆抗体ER-MP42/HM1091/100µg
商品编号: HM1091
品牌: hycultbiotech
市场价: ¥6432.00
美元价: 3859.20
产地: 美国(厂家直采)
公司:
产品分类: 单克隆抗体
公司分类: monoclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Description:MHCclassI,Mouse,mAbER-MP42

ThemonoclonalantibodyER-MP42specificallyreactswithmajorhistocompatibilitycomplex(MHC)classIantigensofthemouseand,therefore,itisavaluabletoolforstudyingcytotoxicT-cellinteractionswithclassIpositiveantigenpresentingcells.TheprimaryimmunologicalfunctionofMHCmoleculesistobindandpresentantigenicpeptidesonthesurfacesofcellsforrecognitionbytheantigen-specificTcellreceptors(TCRs)oflymphocytes.MHCclassImoleculesareexpressedonthesurfacesofmostcellsandarerecognizedbyCD8-positivecytotoxicT-cells,anessentialstepforinitiatingtheeliminationofvirallyinfectedcellsbyT-cell-mediatedlysis.MHCclassImoleculesareheterodimerscomposedofanalpha(44kD)andabeta(betamicroglobulin,11kD)subunit.Thefirsttwostructuraldomainsofthealphasubunitassociatetoformthepeptide-bindingpocket.ThemonoclonalantibodyER-MP42reactswithMHCclassI,anantigenthatisexpressedbyallsomaticcellsatvaryinglevels.Lymphocytesarehighlypositive,whereasfibroblastsandneuronsshowonlyalowlevelofantigenexpression.ER-MP42recognizesmurineMHCclassImoleculesonthesurfaceofcellsofthefollowinghaplotypes:H-2Fv,H-2Dd,H-2k,q,s.Weakerreactivityisfoundinmiceofthefollowinghaplotypes:H-2p,r,w7,w22.MHCclassImoleculesofotherhaplotypesarenotrecognizedbyER-MP42.Thereisnocross-reactivitywithhumanMHCclassImolecules.

Specifications:

CatalognumberHM1091
ProducttypeMonoclonalantibodies
Quantity100µg
Formulation1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide.
ApplicationFlowcytometry,Frozensections
UseForimmunohistologyandflowcytometry,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.
IsotypeRatIgG2a
SpeciesMouse
StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.
PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct.
DiseaseInfectiousdiseases
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。