4000-520-616
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当前位置: 首页 > 产品中心 > monoclonal_antibody > Hycult Biotech/Ly-6C,小鼠,单克隆抗体ER-MP20/HM1082/100µg
商品详细Hycult Biotech/Ly-6C,小鼠,单克隆抗体ER-MP20/HM1082/100µg
Hycult Biotech/Ly-6C,小鼠,单克隆抗体ER-MP20/HM1082/100µg
Hycult Biotech/Ly-6C,小鼠,单克隆抗体ER-MP20/HM1082/100µg
商品编号: HM1082
品牌: hycultbiotech
市场价: ¥6432.00
美元价: 3859.20
产地: 美国(厂家直采)
公司:
产品分类: 单克隆抗体
公司分类: monoclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Description:Ly-6C,Mouse,mAbER-MP20

ThemonoclonalantibodyER-MP20specificallyreactswithmousemacrophageprecursorcellsinthemid-stageoftheirdevelopment(lateCFU-M,monoblastsandmonocytes).Theantigenisa14kDsurfaceproteinwhichisverysimilartoLy-6CandmaybeanalogoustohumanCD59.ItisinducIBLebyIFN-alpha,IFN-betaandIFN-gamma.Intissuesections,theantigenisfoundonmacrophageprecursorsubpopulations.Inthebonemarrowandhemopoieticislandsofthelymphoidorgans,andinthespleen.ActivatedmacrophagesininflammatorytissuesalsoexpresstheER-MP20-relatedantigen.ThemonoclonalantibodyER-MP20hasbeenraisedafterimmunizationofratswithmousemacrophagecelllinesandreactswithmousemacrophageprecursorcells.Themonoclonalantibodyalsoidentifiesactivatedmacrophagesininflammatorytissueswherethesimultaneoususeofthemurinepan-macrophageMarkerBM8(anti-F4/80)isrecommended.Incombinationwithananti-mouseCD31/PECAM-1antibody,ER-MP20canbeusedtoevaluatethecellularcompositioninmurinebonemarrow(e.g.usingflowcytometricanalysis).ER-MP20alsodetectsawiderangeofendothelialcells.

Specifications:

CatalognumberHM1082
ProducttypeMonoclonalantibodies
Quantity100µg
Formulation1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.02%sodiumazideand0.1%bovineserumalbumin.
ApplicationFlowcytometry,Frozensections,Immunoassays,Paraffinsections
UseForimmunohistologyandflowcytometry,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.
IsotypeRatIgG2a
SpeciesMouse
References1.DeBruijn,Metal;DistinctmousebonemarrowmacrophageprecursorsidentifiedbydifferentialexpressionofER-MP12andER-MP20antigens.EurJImmunol1994,24:2279
2.DeBruijn,Metal;BonemarrowcellularcompositioninListeriamonocytogenesinfectedmicedetectedusingER-MP12andER-MP20antibodies:aflowcytometricalternativetodifferentialcounting.JImmunolMethods1998,217:27
3.Chan,Jetal;Macrophagelineagecellsininflammation:characterizationbycolony-stimulatingfactor-1(CSF-1)receptor(c-Fms),ER-MP58,andER-MP20(Ly-6C)expression.Blood1998,92:1423
4.Henkel,Getal;CommitmenttothemonocyticlineageoccursintheabsenceofthetranscriptionfactorPU.1.Blood1999,93:2849
5.Manitz,Metal;LossofS100A9(MRP14)resultsinreducedinterleukin-8-inducedCD11bsurfaceexpression,apolarizedMICROFILamentsystem,anddiminishedresponsivenesstochemoattractantsinvitro.MolCellBiol2003,23:1034
StorageandstABIlityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.
PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct.
DiseaseAutoimmunity
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。