Hycult Biotech/JAM-C, Mouse, mAb CRAM-18F26/HM1057/100 µg
商品编号：
HM1057
品牌：
hycultbiotech
市场价：
¥9288.00
美元价：
5572.80
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:JAM-C,Mouse,mAbCRAM-18F26
ThemonoclonalantibodyCRAM-18F26recognizesjunctionaladhesionmolecule-C(JAM-C)alsoknownasJAM-2,a45kDcelladhesionmolecule(CAM).JAM-Cisatransmembraneproteinwhichisamemberoftheimmunoglobulinsuperfamilyfoundatintercellularjunctionsofendothelialcells.JAM-CbelongstogetherwithJAM-A(JAMorJAM-1)andJAM-B(VE-JAMorJAM-3)toafamilyofadhesionproteinswithaV-C2immunoglobulindomainorganization.JAMplaysanimportantroleintightjunctionswhereitisinvolvedincell-to-celladhesionthroughhomophilicinteraction.ItcodistributeswithothertightjunctioncomponentsasZO-1,7H6antigen,cingulinandoccludin.JAM-Cispotentiallyinvolvedinthejunctionalsealingofthevascularendothelium,inparticularofhighendothelialvenules(HEV).InadultmurinetissueJAM-Cexpressionisreportedtoberestrictedtohighendothelialvenulesoflymphoidorgans,lymphoendothelialcellsandendothelialcellsinkidney.MonoclonalantibodyCRAM-18F26alsoreactswithhumanJAM-C.Inhumans,JAM-Cexpressionisnotrestrictedtoendothelialcells,butisalsoexpressedonhumanlymphocytes.
Specifications:
| Catalognumber | HM1057 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin. |
| Application | Flowcytometry,Frozensections,Functionalstudies,Immunoassays,Immunoprecipitation |
| ApplicationNotes | ThemonoclonalantibodyCRAM-18F26canbeusedforimmunoprecipitation,immunoassaysasdetectorantibody,immunohistologyonfrozensectionsandflowcytometry.MonoclonalantibodyCRAM-18F26isalsousefulforinhibitionofBIOLOGicalactivity.TheantibodycannotbeusedforWesternblotandimmunohistologyonparaffinsections. |
| Use | Forimmunohistologyandflowcytometry,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forinhibitionofbiologicalactivity,dilutionshavetobemadeaccordingtotheamountsofJAM-Ctobeinhibited. |
| Isotype | MouseIgG2a |
| Species | Mouse |
| Crossreactivity | Human-Yes |
| References | 1.Aurrand-Lions,Metal;JAM-2,anovelimmunoglobulinsuperfamilymolecule,expressedbyendothelialandlymphaticcells.JBiolChem2001,276:2733 2.Aurrand-Lions,Metal;HeterogeneityofendothelialjunctionsisreflectedbydifferentialexpressionandspecificsubcellularlocalizationofthethreeJAMfamilymembers.Blood2001,98:3699 3.Johnson-Leger,Cetal;Junctionaladhesionmolecule-2(JAM-2)promoteslymphocytetransendothelialmigration.Blood2002,100:2479 |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Neurologicaldisorders,Tumorimmunology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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