Hycult Biotech/JAM-C, Mouse, mAb 19H36/HM1056/100 µg
商品编号:
HM1056
品牌:
hycultbiotech
市场价:
¥9288.00
美元价:
5572.80
产品分类:
单克隆抗体
公司分类:
monoclonal_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description:JAM-C,Mouse,mAb19H36
Junctionaladhesionmolecule-C(JAM-C)alsoknownasJAM-2isa45kDcelladhesionmolecule(CAM).JAM-Cisatransmembraneproteinwhichisamemberoftheimmunoglobulinsuperfamilyfoundatintercellularjunctionsofendothelialcells.JAM-CbelongstogetherwithJAM-A(JAMorJAM-1)andJAM-B(VE-JAMorJAM-3)toafamilyofadhesionproteinswithaV-C2immunoglobulindomainorganization.JAMplaysanimportantroleintightjunctionswhereitisinvolvedincell-to-celladhesionthroughhomophilicinteraction.ItcodistributeswithothertightjunctioncomponentsasZO-1,7H6antigen,cingulinandoccludin.JAM-Cispotentiallyinvolvedinthejunctionalsealingofthevascularendothelium,inparticularofhighendothelialvenules(HEV).InadultmurinetissueJAM-Cexpressionisreportedtoberestrictedtohighendothelialvenulesoflymphoidorgans,lymphoendothelialcellsandendothelialcellsinkidney.MonoclonalantibodyCRAM-19H36alsoreactswithhumanJAM-C.Inhumans,JAM-Cexpressionisnotrestrictedtoendothelialcells,butisalsoexpressedonhumanlymphocytes.
Specifications:
Catalognumber | HM1056 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
Application | Flowcytometry,Frozensections,Immunoassays,Immunoprecipitation |
ApplicationNotes | MonoclonalantibodyCRAM-19H36canbeusedforimmunoprecipiation,immunoassaysasdetectorantibody,immunohistologyonfrozensectionsandflowcytometry.AntibodyCRAM-19H36cannotbeusedforWesternblotandimmunohistologyonparaffinsections. |
Use | Forimmunohistologyandflowcytometrydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Isotype | RatIgG2a |
Species | Mouse |
Crossreactivity | Human-Yes |
References | 1.Aurrand-Lions,Metal;JAM-2,anovelimmunoglobulinsuperfamilymolecule,expressedbyendothelialandlymphaticcells.JBiolChem2001,276:2733 2.Johnson-Leger,Cetal;Junctionaladhesionmolecule-2(JAM-2)promoteslymphocytetransendothelialmigration.Blood2002,100:2479 |
StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
Disease | Neurologicaldisorders,Tumorimmunology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。
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