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当前位置: 首页 > 产品中心 > monoclonal_antibody > Hycult Biotech/TLR2, Mouse, mAb 6C2, biotinylated/HM1048/50 µg
商品详细Hycult Biotech/TLR2, Mouse, mAb 6C2, biotinylated/HM1048/50 µg
Hycult Biotech/TLR2, Mouse, mAb 6C2, biotinylated/HM1048/50 µg
Hycult Biotech/TLR2, Mouse, mAb 6C2, biotinylated/HM1048/50 µg
商品编号: HM1048
品牌: hycultbiotech
市场价: ¥4896.00
美元价: 2937.60
产地: 美国(厂家直采)
公司:
产品分类: 单克隆抗体
公司分类: monoclonal_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Description:TLR2,Mouse,mAb6C2,biotinylated

Monoclonalantibody6C2reactswithmouseToll-likereceptor2(TLR2,CD282).Toll-likereceptors(TLR)arehighlyconservedthroughoutevolutionandhavebeenimplicatedintheinnatedefensetomanypathogens.InDrosophilatollisrequiredfortheanti-fungalresponse,whiletherelated18-wheelerisinvolvedinantibacterialdefenses.Inmammals,TLRidentifiedastypeItransmembranesignalingreceptorswithpatternrecognitioncapABIlities,havebeenimplicatedintheinnatehostdefensetopathogens.TLR2hasbeenidentifiedasareceptorthatiscentraltotheinnateimmuneresponsetolipoproteinsofgram-negativebacteria,severalwholegram-positivebacteria,aswellasareceptorforpeptidoglycanandlipoteichoicacidandotherbacterialcellmembraneproducts.AfunctionalinteractionbetweenTLR2andTLR6inthecellularresponsetovariousbacterialproductshasbeendiscovered.ThecurrentlyacceptedparADIgmregardsTLR2asanessentialreceptorformanyeubacterialcellwallcomponents,includinglipoproteinsandpeptidoglycan.Bacterialspeciesasdiverseasmycobacteria,spiRochetes,mycoplasma,Staphylococcusaureus,andStreptococcuspneumoniaehaveallbeenshowntomediatecellularactivationviaTLR2.

Specifications:

CatalognumberHM1048
ProducttypeMonoclonalantibodies
Quantity50µg
Formulation0.5ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide.
ConjugateBiotin
ApplicationFlowcytometry
ApplicationNotesThemonoclonalantibody6C2canbeusedforflowcytometryandimmunoprecipitation.TheantibodyworksinimmunofluorescenceoffixedRAWcells.TheantibodygivesonlyasmallinhibitionofTLR2(CD282)ligandsinRAWcells.TheantibodyisnotusefulforWesternblotting.
UseForflowcytometrydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.
IsotypeRatIgG2b
SpeciesMouse
References1.Rharbaoui,Fetal;Themycoplasma-derivedmacrophage-activating2-kilodaltonlipopeptidetriggersglobalimmuneactivationonnasalmucosa-associatedlymphoidtissues.InfectImmun2004,72:6978
2.Lan,Jetal;Differentcytokineresponseofprimarycolonicepithelialcellstocommensalbacteria.WorldJGastoenterol2005,11:3375
StorageandstabilityProductshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear.
PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct.
DiseaseInfectiousdiseases
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。