Hycult Biotech/CD180，小鼠，单克隆抗体RP/14，生物素化/HM1032/50µg
商品编号：
HM1032
品牌：
hycultbiotech
市场价：
¥4896.00
美元价：
2937.60
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:CD180,Mouse,mAbRP/14,biotinylated
RADIoprotective105(RP105,CD180)isatype1transmembraneproteinof105kDawithextracellularleucine-richerepeats(LLRs)andashortcytoplasmictail.RP105,assignedasCD180,issimilartoDrosophilaTollintheextracellularLLRs.Radioprotective105(RP105,CD180)expressionislargelyrestrictedtoimmunecellsincludingCD19+Bcellsandmacrophages.HistologicalstudiesshowedthatRP105isexpressedmainlyonmatureBcellsinmantlezones.Antibody-mediated(RP/14)cross-linkingofRP105inducesresistanceagainstirradiation-inducedapoptosis,B-cellproliferation,andup-regulationofacostimulatorymoleculeB7.2,revealingRP105asapotentregulatorofB-cellactivation.RP105(CD180)hasanimportantroleinB-cellactivationbyLPS.ItisimportanttonotethatRP105associateswithMD1,whichisinthiscontextimportantforRP105withrespecttoB-cellsurfaceexpressionandLPSrecognitionandsignalling.MD-1seemstoberequisiteforefficientexpressionofRP105.
Specifications:
| Catalognumber | HM1032 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 50µg |
| Formulation | 0.5ml(100µg/ml)0.2µmfilteredbiotinylatedantibodysolutioninPBS,containing0.02%sodiumazideand0.1%bovineserumalbumin. |
| Conjugate | Biotin |
| Application | Flowcytometry |
| ApplicationNotes | Forflowcytometry,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Use | Forflowcytometrydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Isotype | RatIgG2a |
| Species | Mouse |
| References | 1.Miyake,Ketal;MouseMD-1,amoleculethatisphysicallyassociatedwithRP105andpositivelyregulatesitsexpression.JImmunol1998,161:1348 2.Nagai,Yetal;RequirementforMD-1incellsurfaceexpressionofRP105/CD180andB-cellresponsivenesstolipopolysaccharide.Blood2002,99:1699 |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Autoimmunity,Tumorimmunology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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