Hycult Biotech/CD180, Mouse, mAb RP/14/HM1031/100 µg
商品编号:
HM1031
品牌:
hycultbiotech
市场价:
¥6432.00
美元价:
3859.20
产品分类:
单克隆抗体
公司分类:
monoclonal_antibody
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Description:CD180,Mouse,mAbRP/14
RADIoprotective105(RP105,CD180)isatype1transmembraneproteinof105kDawithextracellularleucine-richrepeats(LLRs)andashortcytoplasmictail.RP105,assignedasCD180,issimilartoDrosophilaTollintheextracellularLLRs.Radioprotective105(RP105,CD180)expressionislargelyrestrictedtoimmunecellsincludingCD19+Bcellsandmacrophages.HistologicalstudiesshowedthatRP105isexpressedmainlyonmatureBcellsinmantlezones.Antibody-mediated(RP/14)cross-linkingofRP105inducesresistanceagainstirradiation-inducedapoptosis,B-cellproliferation,andup-regulationofacostimulatorymoleculeB7.2,revealingRP105asapotentregulatorofB-cellactivation.RP105(CD180)hasanimportantroleinB-cellactivationbyLPS.ItisimportanttonotethatRP105associateswithMD1,whichisinthiscontextimportantforRP105withrespecttoB-cellsurfaceexpressionandLPSrecognitionandsignalling.MD-1seemstoberequisiteforefficientexpressionofRP105.
Specifications:
Catalognumber | HM1031 |
---|---|
Producttype | Monoclonalantibodies |
Quantity | 100µg |
Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin. |
Application | Flowcytometry,Functionalstudies |
ApplicationNotes | Forflowcytometry,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Use | Forflowcytometry,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
Isotype | RatIgG2a |
Species | Mouse |
Alias | RP105,Ly78 |
References | 1.Miyake,Ketal;MouseMD-1,amoleculethatisphysicallyassociatedwithRP105andpositivelyregulatesitsexpression.JImmunol1998,161:1348 2.Nagai,Yetal;RequirementforMD-1incellsurfaceexpressionofRP105/CD180andB-cellresponsivenesstolipopolysaccharide.Blood2002,99:1699 |
StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct. |
Disease | Autoimmunity,Tumorimmunology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。
联络我们