Hycult Biotech/LBP, Mouse, mAb RR433-8/HM1027/100 µg
商品编号：
HM1027
品牌：
hycultbiotech
市场价：
¥9288.00
美元价：
5572.80
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:LBP,Mouse,mAbRR433-8
ThemonoclonalantibodyRR433-8reactshighlyspecificwithmousenaturalandrecombinantLBP.TheantibodyisatypeIIantibodyblockingtheLPSbindingtoCD14.LPSbindingprotein(LBP)isanapproximately60kDaacutephaseproteinthatisproducedbyhepatocytes.ThisproteinstronglybindstoLPSandhasbeenshowntoplayanimportantroleinthehandlingofLPSbythehost.AnumberoffunctionsofLBPhavebeenreported.First,LBPtransfersLPStotheLPSreceptorCD14onmononuclearphagocytes,leADIngtoan100-1,000-foldincreasedsensitivityofthecellstoLPS.FurThermore,LBPcanenhancetheresponseofCD14negativecellsbyaccelerationofLPSbindingtosolubleCD14,acomplexthatstimulatesthesecells.Next,LBPtransfersLPSintoHighDensityLipoprotein(HDL),whicheffectivelyneutralizesitsBIOLOGicalpotency.LBPwasdemonstratedtoprotectmicefromsepticshockcausedbyLPSorgramnegativebacteria.
Specifications:
| Catalognumber | HM1027 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.02%sodiumazideand0.1%bovineserumalbumin. |
| Application | Functionalstudies,Immunoassays,Westernblot |
| ApplicationNotes | TheantibodycanbeusedforfunctionalstudiesinvitroandinvivoaimedatblockingLBP.FurthermoretheantibodyisusefulforimmunoassaysandforWesternblotting. |
| Use | ForWesternblottingdilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:10.ForneutralizationofbiologicalactivitydilutionshavetobemadeaccordingtotheamountsLBPtobeinactivated.Beforeuseinbiologicalassays,theproductmustbefiltersterilizedanddependingontheconcentrationtobeuseddialyzedagainstculturemediumtoremovethesodiumazideadded.PleaseinquireforavailABIlityofazidefreesolutions. |
| Isotype | RatIgG2a |
| Species | Mouse |
| References | 1.LeRoy,Detal;Monoclonalantibodiestomurinelipopolysaccharide(LPS)-bindingprotein(LBP)protectmicefromlethalendotoxemiabyblockingeitherthebindingofLPStoLBPorthepresentationofLPS/LBPcomplexestoCD14.JImmunol1999,162:7454 2.LeRoy,Detal;Criticalroleoflipopolysaccharide-bindingproteinandCD14inimmuneresponseagainstgram-negativebacteria.JImmunol2001,169:2759 |
| Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Infectiousdiseases |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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