Hycult Biotech/Viperin，小鼠，单克隆抗体图谱。VIP/HM1016/100µg
商品编号：
HM1016
品牌：
hycultbiotech
市场价：
¥7752.00
美元价：
4651.20
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:Viperin,Mouse,mAbMaP.VIP
ThemonoclonalantibodyMaP.VIPrecognizesmouseViperin,a42kDaproteinbelongingtotheRSAD2family.ViperinistheabbreviationofVirusinhibitoryproteinendoplasmicreticulum-associatedinterferon-inducIBLe.ItisanevolutionaryconservedproteinthatishighlyinduciblebybothtypeIandtypeIIinterferons.However,littleornoinductionbyinterferongammaisobservedinmonocyticcelllines.Infectionbymanyviruses,includinghumancytomegalovirus(hCMV),hepatitisCvirus,yellowfevervirusandSendaivirus,stronglyinducesviperinexpression,suggestingaroleinthehostantiviralresponse.Viperinhasalsobeenshowntobeimportantforthehostanti-HIVresponses.FurThermore,expressionofviperininhibitsinfluenzareplicationbyperturbingitsreleasefromtheplasmamembrane.Viperinexpressionaltersplasmamembranefluiditybyaffectingformationoflipidraftswhicharedetergent-resistantmembranemicrodomainsknowntobethesitesofinfluenzavirusbudding.HCMVinfectioninducestheredistributionofviperinfromtheendoplasmicreticulumtotheGolgicomplexandultimatelytocytoplasmicvacuoles,suggestingthatviperinmayfunctionatadistinctlevelinthevirallifecycle,atthepointofglycosylatedviralproteintransport.
Specifications:
| Catalognumber | HM1016 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbuminand0.02%sodiumazide. |
| Application | Flowcytometry,Immunofluorescence,Immunoprecipitation,Westernblot |
| Use | ForflowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Immunogen | Recombinantmouseviperinfragment(residues92-362) |
| Isotype | MouseIgG2a |
| Species | Mouse |
| Crossreactivity | Human-Yes |
| Alias | RADIcalS-adenosinemethioninedomain-containingprotein2,Virusinhibitoryproteinendoplasmicreticulum-associatedinterferon-inducible,Cytomegalovirus-inducedgene5protein,Cig5 |
| References | 1.Wang,Xetal;Theinterferon-inducibleproteinviperininhibitsinfluenzavirusreleasebyperturbinglipidrafts.CellHostMicrobe2007,2:96 2.Lackman,Retal;Innateimmunerecognitiontriggerssecretionoflysosomalenzymesbymacrophages.Traffic2007,8:11793.Hinson,E.,etal.ViperinIsHighlyInducedinNeutrophilsandMacrophagesduringAcuteandChronicLymphocyticChoriomeningitisVirusInfection2010,J.Immunol.184:5723. |
| StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Infectiousdiseases |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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