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Hycult Biotech/SAA-1, Human, mAb Reu86.5, immuno assay antibody/HM2101-IA/0.5 mg
Hycult Biotech/SAA-1, Human, mAb Reu86.5, immuno assay antibody/HM2101-IA/0.5 mg
商品编号：
HM2101-IA
品牌：
hycultbiotech
市场价：
¥23664.00
美元价：
14198.40
产品分类：
标签抗体
公司分类：
Tag_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:SAA-1,Human,mAbReu86.5,immunoassayantibody
TheserumamyloidA(SAA)familycomprisesanumberofdifferentiallyexpressedapolipoproteins,acute-phaseSAA1andSAA2,theformerbeingthemajorcomponentinplasma,andconstitutiveSAAs(C-SAAs).AlthoughtheliveristheprimarysiteofsynthesisofbothSAAtypesextrahepaticproductionhasbeenreported.Theinvivoconcentrationsincreasebyasmuchas1000-foldduringinflammation.Severalstudieshavestresseditsimportanceinthediagnosisandmonitoringofvariousdiseases.PathologicalSAAvaluesareoftendetectedinassociationwithnormalCRPconcentrations;SAArisesearlierandmoresharplythanCRP.
Recently,abroaderviewofSAAexpressionandfunctionhasbeenemerging.ExpressionstudiesshowproductionofSAAproteinsinhistologicallynormal,atherosclerotic,Alzheimer,inflammatory,andtumortissues.SAAhasbeenfoundtohavebindingsitesforhighdensitylipoproteins,calcium,laminin,andheparin/heparan-sulfate.Alsoadhesionmotifswereidentifiedandnewfunctions,affectingcelladhesion,migration,proliferationandaggregationdiscovered.ThesefindingsemphasizetheimportanceofSAAinvariousphysiologicalandpathologicalprocesses,includinginflammation,atherosclerosis,thrombosis,AA-amyloidosis,rheumatoidarthritis,andneoplasia.SAAhasalsoanumberofimmunomodulatoryroles,itcaninducechemotaxisandadhesionmoleculeexpression,hascytokine-likepropertiesandcanpromotetheupregulationofmetalloproteinases.Itenhancesthebindingofhigh-densitylipoproteintomacrophagesandthushelpsinthedeliveryoflipidstositesofinjuryforuseintissuerepair.Itisthusthoughttobeanintegralpartofthediseaseprocesses.Inaddition,recentexperimentssuggestthatSAAmayplaya"housekeeping"roleinnormalhumantissues.
ElevatedlevelsofSAAovertimepredisposetosecondaryamyloidosis,extracellularaccumulationofamyloidfibrils,derivedfromacirculatingprecursor,invarioustissueandorgans.Themostcommonformofamyloidosisoccurssecondarytochronicinflammatorydisease,particularlyrheumatoidarthritis.
TheantibodyisraisedagainsthumanSAAandHelixPomatiaHaemocyanine.ItreactswiththeSAA-1type.
Recently,abroaderviewofSAAexpressionandfunctionhasbeenemerging.ExpressionstudiesshowproductionofSAAproteinsinhistologicallynormal,atherosclerotic,Alzheimer,inflammatory,andtumortissues.SAAhasbeenfoundtohavebindingsitesforhighdensitylipoproteins,calcium,laminin,andheparin/heparan-sulfate.Alsoadhesionmotifswereidentifiedandnewfunctions,affectingcelladhesion,migration,proliferationandaggregationdiscovered.ThesefindingsemphasizetheimportanceofSAAinvariousphysiologicalandpathologicalprocesses,includinginflammation,atherosclerosis,thrombosis,AA-amyloidosis,rheumatoidarthritis,andneoplasia.SAAhasalsoanumberofimmunomodulatoryroles,itcaninducechemotaxisandadhesionmoleculeexpression,hascytokine-likepropertiesandcanpromotetheupregulationofmetalloproteinases.Itenhancesthebindingofhigh-densitylipoproteintomacrophagesandthushelpsinthedeliveryoflipidstositesofinjuryforuseintissuerepair.Itisthusthoughttobeanintegralpartofthediseaseprocesses.Inaddition,recentexperimentssuggestthatSAAmayplaya"housekeeping"roleinnormalhumantissues.
ElevatedlevelsofSAAovertimepredisposetosecondaryamyloidosis,extracellularaccumulationofamyloidfibrils,derivedfromacirculatingprecursor,invarioustissueandorgans.Themostcommonformofamyloidosisoccurssecondarytochronicinflammatorydisease,particularlyrheumatoidarthritis.
TheantibodyisraisedagainsthumanSAAandHelixPomatiaHaemocyanine.ItreactswiththeSAA-1type.
Specifications:
| Catalognumber | HM2101-IA |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 0.5mg |
| Formulation | 0.5mgof0.2μmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel) |
| Application | Frozensections,Immunoassays,Paraffinsections,Westernblot |
| Use | Forwesternblottingandimmunohistologydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:10. |
| Isotype | MouseIgG1 |
| Species | Human |
| Crossreactivity | Mouse-Yes |
| References | 1.Hazenberg,Betal;ImmunohistochemicaldetectionofAmyloidAAinformaline-fixedparaffin-embeddedrectalbiopsieswiththemonoclonalantibodyanti-humanSAAantibodyReu.86.2.AmyloidandAmyloidosis1990,VIthInternationalSymposiumonAmyloidosis:809 2.Hazenberg,Betal;MonoclonalantibodybasedELISAforhumanSAA.AmyloidandAmyloidosis,eds.LBNatvigetal,KluwerAcadPubl1990:898 3.Wilkins,Jetal;RapidautomatedenzymeimmunoassaysofSerumAmyloidA.ClinChem1994,40:1284 4.Hazenberg,Betal;AquantitativemethodfordetectingdepositsofamyloidAproteininaspiratedfattissueofpatientswitharthritis.AnnRheumDis1999,58:96 |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Autoimmunity |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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