Hycult Biotech/C3/C3a，人，单克隆抗体2898，免疫分析抗体/HM2075-IA/0.5 mg
商品编号：
HM2075-IA
品牌：
hycultbiotech
市场价：
¥20832.00
美元价：
12499.20
产品分类：
标签抗体
公司分类：
Tag_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:C3/C3a,Human,mAb2898,immunoassayantibody
Themonoclonalantibody2898recognizestheC-terminusofhumancomplementproteinC3a.TheantibodyrecognizesintactC3,C3aaswellasC3a-desArg.C3isthemostabundantproteinofthecomplementsystemwithserumproteinlevelsofabout1.3mg/ml.Thecomplementsystemisanimportantpartofthehumoralresponseininnateimmunity,consistingofthreedifferentpathways.Thethirdcomplementcomponent,C3,iscentraltotheclassical,alternativeandlectinpathwaysofcomplementactivation.Activationproductsofthecomplementcascadecontainneo-epitopesthatarenotpresentintheindividualnativecomponents.Monoclonalantibodiesdetectingneo-epitopeshavebeenusedfordirectquantificationofactivationatdifferentstepsinthecomplementcascade.ThesynthesisofC3istissue-specificandismodulatedinresponsetoavarietyofstimulatoryagents.AninheriteddeficiencyofC3predisposesthepersontofrequentassaultsofbacterialinfections.Inulcerativecolitis,andidiopathicchronicinflammatoryboweldisease,thedepositionofC3inthediseasedmucosahasbeenreported.ProteolysisbycertainenzymesresultsinthecleavageofC3releasingC3aanaphylatoxinandC3b.C3aisaproteinof74aminoacids.C3aitselfisveryshort-livedandinserumiscleavedrapidlyintothemorestableC3a-desArg(alsocalledacylationstimulatingprotein,ASP).Therefore,measurementofC3a-desArgallowsreliableconclusionsaboutthelevelofcomplementactivationinthetestsamples.
C3aisamediatoroflocalinflammatoryprocesses.Itinducessmoothmusclecontraction,increasesvascularpermeABIlity,andcauseshistaminereleasefrommastcellsandbasophilicleukocytes.C3aisinvolvedininflammatoryreactionsseeningram-negativebacterialsepsis,trauma,ischemicheartdisease,post-dialysissyndromeandavarietyofautoimmunediseases.
C3aisamediatoroflocalinflammatoryprocesses.Itinducessmoothmusclecontraction,increasesvascularpermeABIlity,andcauseshistaminereleasefrommastcellsandbasophilicleukocytes.C3aisinvolvedininflammatoryreactionsseeningram-negativebacterialsepsis,trauma,ischemicheartdisease,post-dialysissyndromeandavarietyofautoimmunediseases.
Specifications:
| Catalognumber | HM2075-IA |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 0.5mg |
| Formulation | 0.5mgof0.2µmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel). |
| Application | Immunoassays,Westernblot |
| ApplicationNotes | W:AreducedsampletreatmentandSDS-PAGEwasused.Thebandsizeis~95and8.2kDaforC3andC3arespectively(Ref.1). |
| Use | ForWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Immunogen | PeptideCARASHLGLA(lastnineaminoacidsofC3a-desArg) |
| Isotype | MouseIgG1 |
| Species | Human |
| Alias | ComplementproteinC3 |
| PositiveControl | Humanplasma |
| References | 1.Hartmann,Hetal;RapidquantificationofC3aandC5ausingacombinationofchromatographicandimmunoassayprocedures.JImmunolMeth1993,166:35 2.Smalley,Detal;Proteomicdiscoveryof21proteinsexpressedinhumanplasma-derivedbutnotplatelet-derivedmicroparticles.ThrombHaemost2007,97:67 |
| Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforatleastoneyear.Theexactexpirydateisindicatedonthelabel. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultfromtheuseorderivationofthisproduct. |
| Disease | Infectiousdiseases,Nephrology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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