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Hycult Biotech/CD200R3, Mouse, mAb Ba91, functional study antibody, low endotoxin/HM1104-FS/0.5 mg
Hycult Biotech/CD200R3, Mouse, mAb Ba91, functional study antibody, low endotoxin/HM1104-FS/0.5 mg
商品编号：
HM1104-FS
品牌：
hycultbiotech
市场价：
¥26232.00
美元价：
15739.20
产品分类：
标签抗体
公司分类：
Tag_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:CD200R3,Mouse,mAbBa91,functionalstudyantibody,lowendotoxin
ThemonoclonalantibodyBa91recognizesmouseCD200Receptor-like3(CD200R3),aproteinof~38kDaor~74kDa(reducedornon-reducedcondition,respectively).CD200R3presumablyexistsasadisulfide-linkeddimeronthecellsurface.TheOX-2,orCD200receptor(CD200R),belongstotheimmunoglobulinsuperfamily.CD200RcontainstwoIg-likeextracellulardomainsandmediatesinhibitorysignalsinmyeloidcells.MicedeficientfortheligandCD200developenhancedexperimentalallergicencephalomyelitisandcollagen-inducedarthritis.UnlikeCD200R,theCD200R-likereceptorsfunctionsasactivatingreceptors.TheycontainshortcytoplasmictailsandalysineresidueinthetransmembraneregionandarelikelytosignalviaadaptorproteinssuchasDAP12,DAP10,FcRg,orCD3z.CD200R3isexpressedpreferentiallyoncellsofthemyeloidlineage,includingmastcellsandbasophils.Bothcelltypesareinvolvedinthehostdefensesystemagainstpathogensandinthedevelopmentofallergicdisorders.Theyfunctionasindependentessentialinitiatorsofallergicreactions.Basophilsaretheleastcommonleukocytesintheperipheralbloodaccountingapproximately0.5%ofallleukocytes.InvivodepletionofbasophilsbyusingmonoclonalantibodyprovedtheessentialroleofbasophilsinthedevelopmentandmaintenanceofIgE-mediatedchronicallergicinflammation.TheactivatingCD200receptors,likeCD200R3,playanimportantroleinIgE-independentmastcellandbasophilactivation.MonoclonalantibodyBa91activatesbasophilsexvivoandelicitssystemicanaphylaxiswhenadmiNISTeredinvivo.Cross-linkingofCD200R3onMC/9cellsbymonoclonalantibodyBa91inducesdegranulation.MonoclonalantibodyBa91isalsousefulfordepletionofbasophils.
Specifications:
| Catalognumber | HM1104-FS |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 0.5mg |
| Formulation | 0.5mg(100µg/ml)0.2µmfilteredantibodysolutioninPBS-(exactconcentrationisindicatedonthelabel) |
| Application | Flowcytometry,Functionalstudies,Immunoprecipitation,Westernblot |
| Use | Forflowcytometry,andimmunoprecipitation,ilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.Forfunctionalstudies,invitrodilutionshavetobeoptimizedinuser"sexperimentalsetting. |
| Immunogen | Mouseprimarybasophils |
| Isotype | RatIgG2a |
| Species | Mouse |
| Alias | CD200R3,CD200RLb,OX-2Receptor3 |
| References | Kojima,Tetal;MastcellsandbasophilsareselectivelyactivatedinvitroandinvivothroughCD200R3inanIgE-independentmanner.JImmunol2007,179:7093 |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct. |
| Disease | Autoimmunity |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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