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Hycult Biotech/Collagen II，小鼠，单克隆抗体M2139，功能研究抗体，低内毒素/HM1063-FS/0.5 mg
Hycult Biotech/Collagen II，小鼠，单克隆抗体M2139，功能研究抗体，低内毒素/HM1063-FS/0.5 mg
商品编号：
HM1063-FS
品牌：
hycultbiotech
市场价：
¥26232.00
美元价：
15739.20
产品分类：
标签抗体
公司分类：
Tag_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:CollagenII,Mouse,mAbM2139,functionalstudyantibody,lowendotoxin
ThemonoclonalantibodyM2139reactswiththeJ1epitope(triplehelicalposition551-564)ofcollagentypeII.Collagenisastructuralproteininbone,cartillageandconnectivetissue.CollagentypeII(CII)isthemajorcollagenofthenucleuspulposa(acomponentofspine),cartilageandvitreous(acomponentoftheeye).Themostcommonlyusedanimalmodelforrheumatoidarthritis(RA)isthecollagen-inducedarthritis(CIA).TransferofcollagentypeIIspecificmonoclonalantibodiesinducesanacuteformofarthritis(collagentypeIIantibodyinducedarthritis,CAIA).ThemonocolonalantibodyM2139hasbeenshowntoinduceCAIAinnaïvemiceafterinjectionoflipopolysacharide(LPS).However,incombinationwiththemonoclonalantibodyCIIC1,bindingtotheC1epitopeofCII,thepairofmonoclonalantibodiesinducearthritisindifferentstrainsofmicewithoutanyotherstimulants.Thepresenceofsecondarystimulus,LPS,increasesthediseaseincidenceandseverity.ThemonoclonalantibodyM2139iscrossreactivewithrat,bovine,chickenandhumanCII.
Specifications:
| Catalognumber | HM1063-FS |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 0.5mg |
| Formulation | 0.5mg-(100µg/ml)0.2µmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel) |
| Application | Functionalstudies,Immunoassays,Paraffinsections |
| ApplicationNotes | ThemonoclonalantibodyM2139canbeusedforfunctionalstudiesandforimmunohistologyonparaffinembeddedsections.FurThermorethemonoclonalantibodyM2139isusefulinimmunoassaysascoatinganddetection. FS:M2139supressestheself-assemblyofCIIintofibrils(ref.2) |
| Use | Forimmunohistologydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:25. |
| Isotype | MouseIgG2b |
| Species | Mouse |
| Crossreactivity | Bovine-Yes,Chicken-Yes,Human-Yes,Rat-Yes |
| References | 1.Nandakumar,Ketal;CollagenTypeII-specificmonoclonalantibody-inducedarthritisinmice.Descriptionofthediseaseandtheinfluenceofage,sexandgenes.AmJPathol2003,163:1827 2.Nandakumar,Ketal;CollagentypeII(CII)-specificantibodiesinducearthritisintheabsenceofTorBcellsbutthearthritisprogressionisenhancedbyCII-reactiveTcells.ArthritisResTher2004,6:R544 3.Cook,Aetal;Urokinase-typeplasminogenactivatorandarthritisprogression:roleinsystemicdiseasewithimmunecomplexinvolvement.ArthritisResearch&Therapy2010,12:R37 |
| StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Autoimmunity |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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