Hycult生物技术/胶原蛋白II，小鼠，单克隆抗体CIIC1，功能研究抗体，低内毒素/HM1062-FS/0.5 mg
商品编号：
HM1062-FS
品牌：
hycultbiotech
市场价：
¥26232.00
美元价：
15739.20
产品分类：
标签抗体
公司分类：
Tag_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:CollagenII,Mouse,mAbCIIC1,functionalstudyantibody,lowendotoxin
ThemonoclonalantibodyCIICIreactswiththeC1epitope(triplehelicalposition358-364)ofcollagentypeII.Collagenisastructuralproteininbone,cartillageandconnectivetissue.CollagentypeII(CII)isthemajorcollagenofthenucleuspulposa(acomponentofspine),cartilageandvitreous(acomponentoftheeye).Themostcommonlyusedanimalmodelforrheumatoidarthritis(RA)isthecollagen-inducedarthritis(CIA).TransferofcollagentypeIIspecificmonoclonalantibodiesinducesanacuteformofarthritis(collagentypeIIantibodyinducedarthritis,CAIA).ThemonocolonalantibodyCIIC1hasbeenshowntoinduceCAIAinnaïvemiceafterinjectionoflipopolysacharide(LPS).However,incombinationwiththemonoclonalantibodyM2139,bindingtotheJ1epitopeofCII,thepairofmonoclonalantibodiesinducearthritisindifferentstrainsofmicewithoutanyotherstimulants.Thepresenceofsecondarystimulus,LPS,increasesthediseaseincidenceandseverity.ThemonoclonalantibodyCIIC1iscrossreactivewithrat,bovine,chickenandhumanCII.
Specifications:
| Catalognumber | HM1062-FS |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 0.5mg |
| Formulation | 0.5mg(100µg/ml)0.2µmfilteredantibodysolutioninPBS(exactconcentrationisindicatedonthelabel) |
| Application | Frozensections,Functionalstudies,Immunoassays,Paraffinsections |
| ApplicationNotes | ThemonoclonalantibodyCIICIcanbeusedforfunctionalstudiesandforimmunohistologyonfrozenandparaffinembeddedsections.FurThermorethemonoclonalantibodyCIICIisusefulinimmunoassaysascoatinganddetection. |
| Use | Forimmunohistologydilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:10. |
| Isotype | MouseIgG2a |
| Species | Mouse |
| Crossreactivity | Bovine-Yes,Chicken-Yes,Human-Yes,Rat-Yes |
| References | 1.Nandakumar,Ketal;CollagenTypeII-specificmonoclonalantibody-inducedarthritisinmice.Descriptionofthediseaseandtheinfluenceofage,sexandgenes.AmJPathol2003,163:1827 2.Nandakumar,Ketal;CollagentypeII(CII)-specificantibodiesinducearthritisintheabsenceofTorBcellsbutthearthritisprogressionisenhancedbyCII-reactiveTcells.ArthritisResTher2004,6:R544 |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Autoimmunity |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
联络我们
