Recent studies have indicated increased concentrations of the soluble form of Mannose Receptor (MR) in plasma of patients with infection diseases such as sepsis, pneumonia and acute hepatitis. MR’s are especially expressed on cell membranes of macrophages and function as Pattern Recognition Receptors (PRR). Exact function and (in-vivo) shedding-mechanism of the soluble form, soluble Mannose Receptor (sMR) is still unknown. Increased sMR’s in plasma can be due to some pathogens in the body which stimulate the (in-vivo) shedding mechanism of the MR’s. sMR’s which are bound to the mannose residues of these pathogens, prevent it from being recognized and phagocyted by MR’s. As a result, the innate immunity is slowly suppressed and a vicious circle (which increases the sMR’s in plasma) is created. The body does this probably to partly slow the innate immunity to prevent going out of balance. When the disease being treated, the pathogens which are present in the body of the patient, will be less and less . In the body becoming less cleaved mannose receptors and the sMR in plasma will gradually decrease. The measurement of sMR’s in plasma may be important for the diagnoses/monitoring of diseases such as sepsis, pneumonia and acute hepatitis.