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当前位置: 首页 > 产品中心 > Other_recombinant_protein > 海科生物技术/FABP4,小鼠,重组|海科生物技术/HC1104
商品详细海科生物技术/FABP4,小鼠,重组|海科生物技术/HC1104
海科生物技术/FABP4,小鼠,重组|海科生物技术/HC1104
海科生物技术/FABP4,小鼠,重组|海科生物技术/HC1104
商品编号: HC1104
品牌: hycultbiotech
市场价: ¥5280.00
美元价: 3168.00
产地: 美国(厂家直采)
公司:
产品分类: 其它重组蛋白
公司分类: Other_recombinant_protein
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Adipocyte Fatty Acid Binding Protein (A-FABP), also known as FABP4, aP2 and ALBP, is a 15 kDa protein and is one of the most abundant proteins in mature adipocytes. Human and mouse A-FABP share 91% amino acid sequence homology. Several adipokines from adipose tissues have been identified. The y mediate the cross talk between adipose tissue and the cardiovascular system. This interactionbetween adipose tissue, macrophages and several inflammatory cells leads to expression of, besides A-FABP, among others TNF-α, IL-6, MCP-1, leptin, lipocalin-2 andPai-1.A-FABP is expressed in macrophages and lymphocytes. A-FABP plays a role in the intracellular utilization of fatty acids, transport and metabolism. The putative function of A-FABP is to serve as a lipid-binding chaperone for fatty acids. The protein was identified as a cytoplasmic protein, but is also described to be secreted by adipose tissue in the bloodstream. A-FABP have closely been associated with metabolic syndrome, obesity and atherosclerosis. It is considered as a therapeutic target for these processes in animal models. Several groups have demonstrated an association between serum levels of A-FABP and obesity-related cardiometabolic risk factors, endothelial dysfunction and macrovascular complications of diabetes. The proatherogenic activity of A-FABP is mediated by its direct actions on macrophages, independentlyof lipid metabolism and insulin sensitivity. In line with clinical findings, data from animal studies also supports a role of A-FABP in cardiovascular disease. HC1104 recombinant protein has been isolated from bacteria using affinity purification.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。