海科生物技术公司/组织蛋白酶G,人,肽|海科生物技术公司/HC2138
商品编号:
HC2138
品牌:
hycultbiotech
市场价:
¥5280.00
美元价:
3168.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Cathepsin G (CG) is a serine protease originating from human neutrophils. Serine proteases are a class of proteases with the amino acid serine as the key residue of their enzymatic center, which initiates the proteolytic cleavage of specific target proteins, the protease substrates. CG is, together with neutrophil elastase (NE), and proteinase 3 (PR3), involved in bacterial defense. For instance CG is crucial for resistance against infection with Staphylococcus aureus and contributes to protection against several fungal infections. In addition, CG mediates (together with NE and PR3) regulatory functions that shape the inflammatory response. Once released in the extracellular environment, CG is able to proteolytically modify chemokines such as CXCL5 and CCL15 thereby increasing their chemotactic activity. CG has also been implicated in the processing of pro-form of interleukin-1 to its active form, to degrade mature TNF and inactivate IL-6. Given the prominent role in inflammation, CG is involved in the pathophysiology of several serious human inflammatory diseases, such as chronic obstructive pulmonary disease (COPD), Crohn"s disease, rheumatoid arthritis, cystic fibrosis and other conditions clinically manifested by excessive inflammatory reactions.
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。
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