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Hycult Biotech/Elafin, Human, Recombinant/HC4011/50 µg
Hycult Biotech/Elafin, Human, Recombinant/HC4011/50 µg
商品编号：
HC4011
品牌：
hycultbiotech
市场价：
¥13720.00
美元价：
8232.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:Elafin,Human,Recombinant
ElafinisanepithelialproteinaseinhibitoralsoknownundervariousothernamessuchasSkin-derivedAntileukoproteinase(SKALP)andElastase-SpecificInhibitor(ESI).ElafinbelongstotheTrappingenefamilyandwasgiventhesystematicnameTrappin-2.TheTrappinfamilyisdefinedbyaN-terminaltransglutaminasesubstratedomainandaC-terminalfourdisulphidecore.Trappinshavebeensuggestedtoplayaroleintheregulationofinflammationandinprotectionagainsttissuedamageinstratifiedepithelia.Elafinisaninhibitorofleukocyteelastaseandproteinase-3andinadditionitisasubstratefortransglutaminases.Theproteinisconstitutivelyexpressedinvariousepitheliaincludingthoseofhairfollicles,oesophagus,vaginaandoralcavity.Elafinisnotpresentinnormalhumanskinbutisstronglyinducedduringinflammationasinpsoriasisandwoundhealing.Thefull-lengthproteinistranslatedasa12.3kDaproteinof117aminoacidstermedpre-elafinorTrappin-2.Cleavageofthesignalpeptideyieldsamatureproteinwithamolecularmassof9.9kDa.The9.9kDasecretedproteinisthemajorformfoundinculturemedium.Inskinextractsa6kDaformcomprisingthe57mostC-terminalaminoacidsispresent,whichistheformofelafinoriginallydescribedbyWiedowetal.Inserumboththe9.9andthe6kDaformappeartobepresent.
Specifications:
| Catalognumber | HC4011 |
|---|---|
| Producttype | Proteins |
| Quantity | 50µg |
| Species | Human |
| Formulation | LyophilizedproductinPBS,containing50µg.Reconstitutethevialbypipetting1mldistilledordeionizedwater(Caution:vialisundervacuum). |
| Use | FordilutionsuseproteinstABIlizedphosphatebufferedsaline,pH7.(Neveruseserum/plasma). |
| Storageandstability | Lyophilizedproductshouldbestoredat4°C.Afterreconstitutionstorestocksolutionsinaliquotsat-20°C.Avoidrepeatedfreezingandthawing.Underrecommendedstorageconditions,productisstableformorethanoneyear. |
| References | 1.Wiedow,Oetal;Elafin:anelastase-specificinhibitorofhumanskin.Purification,characterization,andcompleteaminoacidsequence.JBiolChem1990,265:14791Erratumin:JBiolChem1991,266:3356 2.Ying,Qetal;Kineticsoftheinhibitionofhumanleukocyteelastasebyelafin,a6-kilodaltonelastase-specificinhibitorfromhumanskin.Biochemistry1993,32:1866 3.Schalkwijk,Jetal;Thetrappingenefamily:proteinsdefinedbyaN-terminaltransglutaminasesubstratedomainandaC-terminalfour-disulphidecore.BiochemJ1999,340:569 4.Ying,Qetal;Kineticsoftheinhibitionofproteinase3byelafin.AmJRespirCellMolBiol2001,24:83 |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Autoimmunity,Gastroenterology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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