Hycult Biotech/LBP，人，肽/HC4030-05/0.5 mg
商品编号：
HC4030-05
品牌：
hycultbiotech
市场价：
¥15696.00
美元价：
9417.60
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:LBP,Human,Peptide
LPSbindingprotein(LBP)isanapproximately60kDaacutephaseproteinthatisproducedbyhepatocytes.ThisproteinstronglybindstoLPSandhasbeenshowntoplayanimportantroleinthehandlingofLPSbythehost.AnumberoffunctionsofLBPhavebeenreported.First,LBPtransfersLPStotheLPSreceptorCD14onmononuclearphagocytes,leADIngtoan100-1,000-foldincreasedsensitivityofthecellstoLPS.FurThermore,LBPcanenhancetheresponseofCD14negativecellsbyaccelerationofLPSbindingtosolubleCD14,acomplexthatstimulatesthesecells.Next,LBPtransfersLPSintolipoproteinswhichneutralizesitsBIOLOGicalpotency.LBPwasdemonstratedtoprotectmicefromsepticshockcausedbyLPSorgramnegativebacteria.TheLBP-peptide,aminoacids86-99,bindslipidAandneutralizesLPSinvivoandinvitro.
Specifications:
| Catalognumber | HC4030-05 |
|---|---|
| Producttype | Proteins |
| Quantity | 0.5mg |
| Species | Human |
| Formulation | Lyophilized,purifiedLBP-peptidefromhumanLBPproteininPBS.Theexactpeptideamountisindicatedonthelabel.Reconstitutethevialbypipettingsterile,endotoxinfreephosphatebufferedsaline. |
| Use | Forneutralizationofbiologicalactivitydilutionshavetobemadeaccordingtotheamountsproteintobeinactivated.FurtherdilutionsshouldbemadebyusingproteinstABIlizedphosphatebufferedsaline,pH7.(Neverusefreshserum/plasma).Beaware:endotoxinwillbindLBP-peptide. |
| Storageandstability | Lyophilizedproductshouldbestoredat4°C.Thestocksolutionshouldbestoredinaliquotsat-70°Cinpolypropylenetubes.LBP-peptidestocksolutionshouldneverbethawedmorethanonce.RepeatedfreezeandthawcycleswillcauselossofLBP-peptideactivity.Underrecommendedstorageconditions,productisstableformorethanoneyear. |
| References | Bucki,Retal;ExtracellularGelsolinbindslipoteichoicacidandmodulatescellularresponsetoproinflammatorybacterialwallcomponents.JofImmunol.2008,181:4936 |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Infectiousdiseases |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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