Hycult Biotech/Ficolin-1, Human, pAb/HP9039/50 µg
商品编号：
HP9039
品牌：
hycultbiotech
市场价：
¥6340.00
美元价：
3804.00
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:Ficolin-1,Human,pAb
ThepolyconalantibodyrecognizeshumanFicolin-1,alsoknownasM-ficolinandficolin/P35-relatedprotein.Ficolinsareafamilyofpatternrecognitionmoleculescontainingbothacollagen-likedomainandafibrinogen-likedomainthatarecapableofactivatingthecomplementsystem,throughassociationwithMASPs,onthesurfaceofmicroorganisms.Inhuman,threeFicolinsareknown:Ficolin-1(M-ficolin),Ficolin-2(L-ficolin),andFicolin-3(H-ficolin).Ficolin-1,ismainlyexpressedbymonocytes,granulocytesandlungcellsandispresentlocallyinareasofinflammation.However,itwasrecentlyalsofoundinserumsuggestingthatFicolin-1alsohasaroleinsystemicimmunitylikeFicolin-2andFicolin-3.FunctionalanalysisofFicolin-1hasdemonstratedthatit’sligandissialicacidpresentonbacteriasincebindingwasabolishedbypriortreatmentofthebacteriawithsialidase.FurThermore,itwasshownthatFicolin-1facilitatestheuptakeofE.colibyaleukemicmonocytelymphomacellline,suggestingthatitfunctionsasaphagocyticreceptoronthesurfaceofcirculatingmonocytes.LowcordbloodconcentrationofFicolin-1hasbeenassociatedwithhighernecrotizingenterocolitis-associatedfatalityandtwoidentifiedSNPsintheFicolin-1geneareassociatedwiththedevelopmentofrheumatoidarthritis.Ficolin-1has75.3%aminoacididentitywithFicolin-2and47.8%identitywithFicolin-3.ItsmRNAispresentinleukocytesandlung.LikeitsfamilymembersFicolin-2andFicolin-3,Ficolin-1isassociatedwithMASPsandsMAPandactivatesthelectinpathway.TheantibodytohumanFicolin-1iscrossreactivewithhumanFicolin-2.
Specifications:
| Catalognumber | HP9039 |
|---|---|
| Producttype | Polyclonalantibodies |
| Quantity | 50µg |
| Formulation | 1ml(50µg/ml)0.2µmfilteredantibodysolutioninPBS,containing0.02%sodiumazideand0.1%bovineserumalbumin. |
| Application | Flowcytometry,Immunofluorescence,Westernblot |
| Use | Forflowcytometry,immunofluorescenceandWesternblottingdilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Isotype | RabbitIg |
| Species | Human |
| References | 1.Liu,Yetal;HumanM-ficolinisasecretoryproteinthatactivatesthelectincomplementpathway.JImmunol2005,175:3150 2.Frederiksen,P.etal;M-ficolin,aninnateimmunedefencemolecule,bindspatternsofacetylgroupsandactivatescomplement.J.Immunol.2005,62:462 |
| StorageandstABIlity | Productshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Cardiologyandmetabolism,Infectiousdiseases |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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