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Hycult Biotech/TNF-RI, Mouse, mAb HM104, FITC/HM1009F/100 µg
Hycult Biotech/TNF-RI, Mouse, mAb HM104, FITC/HM1009F/100 µg
商品编号：
HM1009F
品牌：
hycultbiotech
市场价：
¥10320.00
美元价：
6192.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:TNF-RI,Mouse,mAbHM104,FITC
ThemonoclonalantibodyHM104recognizestheextracellularpartoftheTumorNecrosisFactorReceptortypeI(TNF-RI)ofthemembrane-boundaswellasthesolublereceptor.TNF-RI(~55-60kDa)ispresentonmostcelltypesandisconsideredtoplayaprominentroleincellstimulationbyTNF-alpha.TNF-alphaactivatesinflammatoryresponses,inducesapoptosis,regulatescellularproliferation,andmayevenpromotecancerprogression.TheeffectsofTNF-alphaaremediatedbyTNF-RIandTNF-RII,whichhavebothdistinctandoverlappingdownstreamsignalingcascades.InductionofcytotoxicityandotherfunctionsaremediatedlargelyviaTNF-RI.TNF-RIisequallywellactivatedbyboththe17kDasolubleand26kDamembrane-boundform,whereasTNF-RIIisefficientlyactivatedonlybythemembraneboundformofTNF-alpha.TNF-RIsignalingisinitiatedwhentrimericTNF-alphabindsTNF-RIreceptors.SubsequentTNF-RItrimerizationpromotestherecruitmentofaproximalsignalingcomplexcomposedofTNFReceptorAssociatedproteinwithaDeathDomain(TRADD),ReceptorInteractingProtein(RIP),cellularInhibitorofApoptosisProtein1(cIAP1),TNFReceptorAssociatedFactor2(TRAF2),andlikelyTRAF5.StudieswithTNF-RI-deficientmiceindicatethatTNF-RImediatesmostoftheproliferation,pro-inflammatory,andapoptosis-activatingpathways.
Specifications:
| Catalognumber | HM1009F |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100µg/ml)0.2µmfilteredantibodysolutioninPBS,containing1%bovineserumalbuminand0.02%sodiumazide. |
| Conjugate | FITC |
| Application | Flowcytometry,Frozensections,Immunoassays |
| ApplicationNotes | ThemonoclonalantibodyHM104canbeusedforimmunoassay,andflowcytometry.FurThermore,themonoclonalantibodyHM104isusefulforimmunoprecipitationandimmunohistologyonfrozensections.BeawarethatthereactivityoftheantibodywithsolubleTNF-ReceptorisinhibitedbyhighconcentrationsofbothmouseandhumanTNF-alpha. |
| Use | Forimmunohistology,flowcytometryandWesternblotting,dilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Isotype | RatIgG2a |
| Species | Mouse |
| Alias | CD120a,Tumornecrosisfactorreceptorsuperfamilymember1A,p55/p60,TNF-RI |
| References | 1.Bigini,Petal;ImmunohistochemicallocalizationofTNFαanditsreceptorsintherodentcentralnervoussystem.MethodsMolMed2004,98:73 2.Mennini,Tetal;GlialactivationandTNFR-Iupregulationprecedesmotordysfunctioninthespinalcordofmndmice.Cytokine2004,25:127 3.Ghezzi,Petal;Tumornecrosisfactorasapharmacologicaltarget.MethodsMolMed2004,98:1 |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct. |
| Disease | Autoimmunity,Gastroenterology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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