Hycult Biotech/IL-6, Mouse, mAb MP5-32C11/HM1005-01/100 µg
商品编号：
HM1005-01
品牌：
hycultbiotech
市场价：
¥6432.00
美元价：
3859.20
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:IL-6,Mouse,mAbMP5-32C11
Theantibodyneutralizesmouseinterleukin6(IL-6).Itdoesnotcross-reactwithLPS(thecomponentofthebacterialcellwallwhichisconsideredresponsIBLeforthetoxicityofgram-negativebacteria)andTNFalphanordoesitblockhumanorratIL-6inproliferationassaysusingtheKD83cellline.MP5-32C11inhibitsmouseIL-6-inducedproliferationoftheNFS60myelomonocyticcelllineandKD83plasmacytoma.IL-6isapluripotent20-22kDacytokinewhichplaysaroleinthepathophysiologyofsevereinfectionandregulatestheimmuneresponse,acutephasereactionandhaematopoiesis.IL-6playsacriticalroleinBcelldifferentiationtoplasmacellsandisapotentgrowthfactorforplasmacytomaandmyeloma.ContinuousIL-6geneexpressionmakesanessentialcontributiontoamultisteponcogenesisofplasmacellneoplasia.IL-6isaveryusefulculturesupplementforthegenerationofahighnumberofantibodyproducinghybridomas.
Specifications:
| Catalognumber | HM1005-01 |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 100µg |
| Formulation | 1ml(100μg/ml)0.2μmfilteredantibodysolutioninPBS,containing0.1%bovineserumalbumin. |
| Application | Functionalstudies,Immunoassays,Immunoprecipitation,Westernblot |
| ApplicationNotes | TheantibodycanbeusedforimmunochemicalinvestigationsofmouseIL-6instructuralstudiesandforquantitative/qualitativeimmunochemicaldetectionmethods.TheantibodyneutralizestheBIOLOGicalactivityofmouseIL-6.FurThermoretheantibodyisusefulforWesternblotandastracerantibodyuseinimmunoassayprocedures. |
| Use | ForWesternblottingdilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:10.ForneutralisationofbiologicalactivitydilutionshavetobemadeaccordingtotheamountofIL-6tobeinactivated. |
| Isotype | RatIgG2a |
| Species | Mouse |
| References | 1.Takatsuki,Fetal;HumanrecombinantIL-6/Bcellstimulatoryfactor2augmentsmurineantigen-specificantibodyresponsesinvitroandinvivo.JImmunol1988,141:30722.McKenzie,Detal;AlloantigenpresentationbyBcells.RequirementforIL-1andIL-6.JImmunol1988,141:29073.vanSnick,Jetal;Interleukin-6:anoverview.AnnuRevImmunol1990,8:2534.Heinrich,PCetal;Interleukin-6andtheacutephaseresponse.BiochemJ1990,265:6215.Starnes,HFJretal;Anti-IL-6monoclonalantibodiesprotectagainstlethalEscherichiacoliinfectionandlethaltumornecrosisfactor-alphachallengeinmice.JImmunol1990,145:41856.Hirano,Tetal;Interleukin6(IL-6)anditsreceptor:theirroleinplasmacellneoplasias.IntJCellCloning1991,9:1667.Hooghe-Peters,Eetal;Interleukin-1,interleukin-6:messengersintheneuroendocrineimmunesystem?PatholResPract1991,187:622 |
| StorageandstABIlity | Lyophilizedproductshouldbestoredat4°C.Storestocksolutioninaliquotsat–20°C.Repeatedfreezeandthawcycleswillcauselossofactivity.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Autoimmunity,Tumorimmunology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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