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当前位置: 首页 > 产品中心 > Tag_antibody > Hycult Biotech/PTX3,人,单克隆抗体MNB1,功能研究抗体,低内毒素/HM2241-FS/0.5 mg
商品详细Hycult Biotech/PTX3,人,单克隆抗体MNB1,功能研究抗体,低内毒素/HM2241-FS/0.5 mg
Hycult Biotech/PTX3,人,单克隆抗体MNB1,功能研究抗体,低内毒素/HM2241-FS/0.5 mg
Hycult Biotech/PTX3,人,单克隆抗体MNB1,功能研究抗体,低内毒素/HM2241-FS/0.5 mg
商品编号: HM2241-FS
品牌: hycultbiotech
市场价: ¥19640.00
美元价: 11784.00
产地: 美国(厂家直采)
公司:
产品分类: 标签抗体
公司分类: Tag_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Description:PTX3,Human,mAbMNB1,functionalstudyantibody,lowendotoxin

ThemonoclonalantibodyMNB1(previouslyknownasclone16B5)recognizeshumanpentraxin3(PTX3),belongingtothelongpentraxinfamily.PTX3isanacute-phaseglycoproteinof~45kDawithglycosylationaccountingforabout10%ofitsmolecularweight.PTX3hasacomplexoligomericstructurewithprotomerslinkedtoeachotherbydisulfidebonds.PTX3expressionistriggeredbyinflammatorycytokines,resultinginhigherlevelsofcirculatingPTX3.SeveralcelltypeshavebeenreportedtoproducePTX3,namelymacrophages,endothelialcells,neutrophilsandsynoviocytes.PTX3isinvolvedinhostdefenseagainstpathogeninfection,intheregulationofthescavengeractivityofmacrophagesanddendriticcells,andinmodulationofcomplementactivitybybindingtoC1q.FurThermore,PTX3hasbeenimplicatedinmatrixdepositionofcumuluscells.Moreover,PTX3interactswithotherBIOLOGicallyactivemolecules,causingtheirfunctionalblockade.Thishasbeendemonstratedforfibroblastgrowthfactor-2(FGF-2),forwhichPTX3actsasaninhibitor,leADIngtoinhibitionofangiogenesis.PTX3,likeotherpentraxinsC-reactiveprotein(CRP)andserumamyloidPcomponent(SAP),bindsapoptoticcellsanddebris.PTX3isusefulasanearlyindicatorofmyocyteirreversIBLeinjuryinischemiccardiomyopathy.PTX3isnotonlyinvolvedininflammatoryvesseldiseasesrelatedtoatherosclerosis,butalsoinpre-eclampsiaandsystemicsmallvesselANCA-associatedvasulitis,inwhichneutrophilsarekeyplayers.Therelationshipbetweentissuedamageandpentraxingenerationisstringentinacuteinjuries.PTX3tunesself-non-selfdiscriminationandtissuerepairduetotherecognitionofdiverseligandsbyPTX3andthroughregulationofeffectorpathways.

Specifications:

CatalognumberHM2241-FS
ProducttypeMonoclonalantibodies
Quantity0.5mg
Formulation0.5mgof0.2μmfilteredproteinGpurifiedantibodysolutioninPBS(exactconcentrationisindicatedonthelabel).
ApplicationFlowcytometry,Functionalstudies,Immunoassays,Westernblot
ApplicationNotesIA:theantibodycanbeusedasdetectionantibody.
W:Reducedsampletreatment.Theexpectedbandsizesareapproximately42and90kDa.
UseDilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50.
ImmunogenHumanrecombinantPTX3
IsotypeRatIgG2b
SpeciesHuman
AliasPTX3,Pentraxin-relatedproteinPTX3,Tumornecrosisfactor-induciblegene14protein,TSG-14
Genename:PTX3,TNFAIP5,TSG14
References1.Bottazzi,Betal;MultimerFormationandLigandRecognitionbytheLongPentraxinPTX3.JBC1997,272:32817
2.Camozzi,Metal;IdentificationofanAntiangiogenicFGF2-bindingSiteintheNTerminusoftheSolublePatternRecognitionReceptorPTX3*.JBC2006,281:22605
3.Jaillon,Setal;ThehumoralpatternrecognitionreceptorPTX3isstoredinneutrophilgranulesandlocalizesinextracellulartraps.JExpMed2007,204:793
4.Jaillon,Setal.EndogenousPTX3translocatesatthemembraneoflateapoptotichumanneutrophilsandisinvolvedintheirengulfmentbymacrophages.CellDeathDiff2009,16:465-474
5.Hamon,Yetal,ProteolyticcleavageofthelongpentraxinPTX3intheairwaysofcysticfibrosispatients.InnImm2013,19:611
StorageandstABIlityProductshouldbestoredat4°C.Underrecommendedstorageconditions,productisstableforatleastoneyear.
PrecautionsForresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandfederalrulesintheuseofthisproduct.HycultBiotechisnotresponsibleforanypatentinfringementsthatmightresultwiththeuseorderivationofthisproduct.
DiseaseCardiologyandmetabolism,Infectiousdiseases
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登,从1994开始制造检测抗体和蛋白质,主要侧重与病理学诊断有关的全套产品研发,既有纯化的重组蛋白和多肽,也有单抗和多抗,是世界一流的先天免疫领域的研究试剂制造商。