Hycult Biotech/C1s，人，单克隆抗体M81，功能研究抗体，低内毒素/HM2108-FS/0.5 mg
商品编号：
HM2108-FS
品牌：
hycultbiotech
市场价：
¥26232.00
美元价：
15739.20
产品分类：
标签抗体
公司分类：
Tag_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:C1s,Human,mAbM81,functionalstudyantibody,lowendotoxin
MonoclonalantibodyM81reactswithanepitopeonhumanCproteinactivatedC1s,asubcomponentofthefirstcomponentofC(C1).ActivatedC1sisaglycosylatedsingle-polypeptidezymogen,MW85kD.ActivationoftheproenzymeC1soccursthroughcleavagebytheactiveformofC1r.Theactivatedprotease,activatedC1s,consistsofadisulfide-linkedHchainandaLchain.ActivatedC1sisaserineproteaseanditscatalyticsiteislocatedintheLchain.ActivationoftheclassicalCpathwayistriggeredbyactivatedC1swhichcleavesC4andC2toformtheC3convertase,C4bC2a.TheepitoperecognisedbytheantibodyM81isdomainIVand/orVofthegamma-domainofactivatedC1s.MonoclonalantibodyM81blocksC4activationandC4bindingtoactivatedC1s.TheantibodyreactsaroundthebindingsiteofC1sandreactswithbothactiveandinactiveC1s.
Specifications:
| Catalognumber | HM2108-FS |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 0.5mg |
| Formulation | 0.5mg(100µ/ml)0.2µmfilteredantibodysolutioninPBS-(exactconcentrationisindicatedonthelabel) |
| Application | Flowcytometry,Frozensections,Functionalstudies,Immunoassays,Immunoprecipitation,Paraffinsections,Westernblot |
| Use | Forimmunohistology,flowcytometryandWesternblottingdilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:10.ForinhibitionofC4activationbyC1sdilutionshavetobemadeaccordingtotheamountsC1stobeinactivated. |
| Isotype | MouseIgG1 |
| Species | Human |
| References | 1.Matsumoto,Metal;ProbingtheC4-bindingsiteonC1swithmonoclonalantibodies,evidenceforaC4/C4b-bindingsiteonthegamma-domain.JImmunol1989,8:2743 2.Nakagawa,Ketal;ComplementC1sactivationindegeneratingarticularcartilageofrheumatoidarthritispatients:immunohistochemicalstudieswithanactiveformspecificantibody.AnnRheumDis1999,58:175 |
| StorageandstABIlity | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Infectiousdiseases,Nephrology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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