Hycult Biotech/JAM-A，人类，单克隆抗体M.Ab.F11，功能研究抗体，低内毒素/HM2099-FS/0.5 mg
商品编号：
HM2099-FS
品牌：
hycultbiotech
市场价：
¥26232.00
美元价：
15739.20
产品分类：
标签抗体
公司分类：
Tag_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:JAM-A,Human,mAbM.Ab.F11,functionalstudyantibody,lowendotoxin
ThemonoclonalantibodyM.Ab.F11recognizesjunctionaladhesionmolecule-A(JAM-A)alsoknownasthehumanplateletF11-Receptor(F11R)andJAM-1isacelladhesionmolecule(CAM).JAM-Aisamemberoftheimmunoglobulinsuperfamilyfoundonthesurfaceofhumanplateletsandatintercellularjunctionsofendothelialcellsandepithelialcells.JAM-AbelongstogetherwithJAM-C(JAM-2)andJAM-B(VE-JAMorJAM-3)toafamilyofadhesionproteinswithaV-C2immunoglobulindomainorganization.JAMplaysanimportantroleintightjunctionswhereitisinvolvedincell-to-celladhesionthroughhomophilicinteraction.ItcodistributeswithothertightjunctioncomponentsasZO-1,7H6antigen,cingulinandoccludin.JAM-Aplaysaroleinplateletaggregation,secretion,adhesion,spreADIng.IntheplateletF11R/JAM-Aisamembraneproteininvolvedin2distinctprocessesinitiatedontheplateletsurface.Antibody-inducedplateletaggregationandsecretionbothdependentonFcgammaRIIandGPIIb/IIIaintegrin,aprocessthatmaybeinvolvedinpathophysiologicalprocessesassociatedwithcertainthrombocytopenias.AntibodymediatedplateletadhesionindependentfromFcgammaRIIorfibrinogenreceptorandthatappearstoplayaroleinphysiologicalprocessesassociatedwithplateletadhesionandaggregation.AphysiologicalrolefortheF11R/JAM-Aproteinwasdemonstratedbyitsphosphorylationafterthestimulationofplateletsbythrombinandcollagen.ApathophysiologicalrolefortheF11R/JAM-AwasrevealedbydemonstratingthepresenceofF11R/JAM-Aantibodiesinpatientswiththrombocytopenia.AdhesionofplateletsthroughtheF11Rresultedineventscharacteristicoftheactionofcelladhesionmolecules(CAMs).RecentdatasuggestsaroleforF11R/JAM-Aintheadhesionofplateletstocytokine-inflamedendothelialcellsandthusinthrombosisandatherosclerosisinducedinnon-denudedbloodvesselsbyinflammatoryprocesses.
Specifications:
| Catalognumber | HM2099-FS |
|---|---|
| Producttype | Monoclonalantibodies |
| Quantity | 0.5mg |
| Formulation | 0.5mg(100µg/ml)0.2µmfilteredsterileantibodysolutioninPBS(exactconcentrationisindicatedonthelabel) |
| Application | Flowcytometry,Functionalstudies,Immunofluorescence,Immunoprecipitation,Westernblot |
| Use | Forimmunofluorescence,flowcytometryandWesternblottingdilutionstobeuseddependondetectionsystemapplied.Itisrecommendedthatuserstestthereagentanddeterminetheirownoptimaldilutions.Thetypicalstartingworkingdilutionis1:50. |
| Isotype | MouseIgG1 |
| Species | Human |
| References | 1.Kornecki,Eetal;Activationofhumanplateletsbyastimulatorymonoclonalantibody.JBiolChem1990,265:10042 2.WalkowiskBetal;Preferreduseofprimaryradiolabeledanti-plateletmonoclonalantibodies.Comparisonofimmunoblottingmethodsfortheanalysisoffunctionaldomainsonhumanplatelets.ThrombRes1992,68:323 3.Naik,Uetal;Mechanismsofplateletactivationbyastimulatoryantibody:cross-linkingofanovelplateletreceptorformonoclonalantibodyF11withtheFcgammaRIIreceptor.BiochemJ1995,310:155 4.Wang,Fetal;Stimulatoryantibody-inducedactivationandselectivetranslocationofproteinkinaseCisoenzymesinhumanplatelets.BiochemJ1995,311:401 5.Sobocka,Metal;CloningofthehumanplateletF11receptor:acelladhesionmoleculememberoftheimmunoglobulinsuperfamilyinvolvedinplateletaggregation.Blood2000,95:2600 6.BABInska,Aetal;TworegionsofthehumanplateletF11-receptor(F11R)arecriticalforplateletaggregation,potentiationandadhesion.ThrombHaemost2002,87:712 |
| Storageandstability | Productshouldbestoredat4 °C.Underrecommendedstorageconditions,productisstableforoneyear. |
| Precautions | Forresearchuseonly.Notforuseinoronhumansoranimalsorfordiagnostics.Itistheresponsibilityoftheusertocomplywithalllocal/stateandFederalrulesintheuseofthisproduct.HycultBiotechisnotresponsIBLeforanypatentinfringementsthatmightresultwiththeuseoforderivationofthisproduct. |
| Disease | Cardiologyandmetabolism,Tumorimmunology |
品牌介绍
荷兰HyCult Biotechnology(HBT)位于荷兰乌登，从1994开始制造检测抗体和蛋白质，主要侧重与病理学诊断有关的全套产品研发，既有纯化的重组蛋白和多肽，也有单抗和多抗，是世界一流的先天免疫领域的研究试剂制造商。
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